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Dopamine enhancement with mucuna pruriens and other dopaminergics

By Serge Kreutz

The greatest advantage of mucuna pruriens (Thai velvet beans) in comparison to all other Parkinson’s medications that are used for sexual enhancement is that effective dosages of mucuna pruriens for sexual enhancement are way lower than dosages that cause severe nausea. One of the reasons for this welcome characteristic is that the L-dopa complex of mucuna pruriens affects dopaminergic neurons in the brain much more than peripheral dopaminergic neurons.

The second choice for dopaminergic stimulation without nausea would be synthetic L-dopa combined with carbidopa, which makes the synthetic L-dopa more bearable.

I have tried other Parkinson’s drugs for sexual enhancement, most of them only a few times, just out of curiosity. Unless you possess a robust health, it is most advisable that you do not reenact my research.

Here now the results from my experimentations, combined with feedback from readers.

One reader mentioned that he used domperidone (doesn’t that sound like a brand of champagne) to counter the nausea caused by lisuride.

“To offset the nausea, one can take some domperidone ahead of time. Domperidone is available in Europe but not the US. It is sold as an anti-emetic; it works by blocking peripheral dopamine receptors (but not blocking the central ones that are responsible for the sexual effects). I got some over the counter in Holland.”

I disagree with his judgment on domperidone. In my own experiments, domperidone has always diminished the sexual effect of dopamine agonists, but never fully suppressed the nausea.

The trick with all dopaminergic agents (even with mucuna pruriens, if one is prone to nausea) that are seldom-used alternative treatments for Parkinson’s disease is to take them with a generous amount of food.

Package inserts usually mention that these medications should be taken with food, but usually do not sufficiently emphasize this.

Seldom-used adjacent treatments for Parkinson’s disease (when the standard treatment of L-dopa has lost effectiveness) are drugs such as liduride, pergolide, cabergoline, bromocriptine, selegiline, and apomorphine, all of which I have tried for sexual enhancement.

All of them cause bad nausea when not taken with food, but some (not all) are tolerable from the nausea perspective when taken with food. They may cause sexual stimulation similar to mucuna pruriens, but none of them ameliorates erectile dysfunction.

If one’s sexual dysfunction (or age-related weakness) is vascular, dopaminergics won’t do any good. Dopamine agonists only enhance desire.

Because nausea is a problem for many who ingest dopamine agonists for sexual parameters, especially when not taken with enough food, some people may feel inclined to try other dopaminergic drugs which are less efficient as Parkinson’s medications.

I myself have tested the MAO-B inhibitor deprenyl. But for me, deprenyl is too similar to amphetamine. It makes me only hyperactive, not hyper-sexed. And like amphetamine, it causes a shrinkage and a loss of the sense of touch in the penis.

I tried amineptine (Survector), an anti-depressant that works by enhancing dopamine levels. Though it makes me feel OK, I don’t get a sexual kick out of it.