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Mucuna pruriens, aka velvet beans, is a plant that contains L-dopa. L-dopa can pass the blood-brain barrier, and is metabolized in the brain into dopamine. Dopamine is an excitatory neurotransmitter that, among many other functions, is a good deal responsible for sexual excitement. But not all velvet beans are the same. In India, velvet beans are grown as animal feed, and those cultivars are void of L-dopa as L-dopa would impede weight gain. Tongkatali.org's mucuna pruriens extract is made from wild Thai mucuna pruriens, naturally high in L-dopa. Be careful of cheating products, even on Amazon, which write a high L-dopa content on labels when in fact these products contain almost no L-dopa. If you want to test: the L-dopa of mucuna pruriens would cause nausea at dosages beyond a few grams.


Mucuna pruriens extract is about the only supplement for sexual desire


By Serge Kreutz


Neurons (nerve cells) in the human brain, mostly an area in the midbrain called substantia nigra, convert L-dopa into the neurotransmitter dopamine. Dopamine regulates motivation, including sexual motivation, and also movement.

Traditionally, a lack of sexual motivation has not been considered a clinical condition. The medical attitude has always been: no libido, no problem.

But when movement is impaired for a lack of dopamine as evident in Parkinson’s disease, this is recognized as a condition that warants medication.

The treatment of first choice for Parkinsons disease is L-dopa. The human body itself manufactures L-dopa via the amino acid L-tyrosine. The enzyme tyrosine hydroxylase does this job. This L-dopa then passes the blood-brain barrier where the another enzyme, aromatic L-amino acid decarboxylase (AADC) converts L-dopa into dopamine. This second transformation is impeded in Parkinson’s disease when decarboxylating neurons die off and are reduced in numbers. By supplying exogenous L-dopa, remaining neurons produce more dopamine. Being a biochemical which the body synthesizes on its own throughout life, the pharmaceutical industry has a hard time to patent it and make exorbitant profits.

Furthermore, L-dopa is also used in the biology of plants, most prominently in mucuna pruriens (velvet beans, cowitch... cow-itch, not co-witch).

Nevertheless, mostly two huge chemicals companies, Monsanto and Ajinomoto, have deviced methods for the industrial production of L-dopa in chemical reactions and by microbial fermentation. However, some people have voiced concerns regarding toxicity associated with these methods of industrial production, and many professionals consider the L-dopa in mucuna pruriens superior.

But pharmaceutical companies are in the business of making money, and to do so, they push their industrial products. Therefore, it's mostly the L-dopa of chemicals corporations that is used in the treatment of Parkinson’s disease.

Apart from the straight use of L-dopa, there are a few other options for increasing dopamine tone in parts of the brain. Dopamine receptor agonists are one such option. Like dopamine itself, these dopamine agonists dock on dopamine receptors (the pharmacological term is: they are ligands for dopamine receptors) and have an effect similar to dopamine. But dopamine agonists never feel as natural as plain L-dopa, and there is a plethora of definitely unwanted side effects.

But for pharmaceutical corporations, a significant aspect of dopamine agonists is that they can be patented, and can turn a profit. Thus dopamine agonists tend to be in the media much more than straight L-dopa and its most common plant source, mucuna pruriens (velvet beans).

For the pharmaceutical industry, Pfizer's Viagra was an eye-opener. It proved that enormous profits could be generated with patented sexual enhancement drugs.

Apomorphine is a case in point. Pharmaceutical companies (Tap Pharmaceuticals, Abbot Laboratories) tried to jump on the Viagra bandwagon with their own patent.

In 2001, they launched Uprima in Europe. Even back then, Uprima wasn't really a new drug. It's active ingredient, apomorphine, has been around for many years as an emetic mostly in veterinary practice. Yes, an emetic, a drug that quickly induces vomiting in dogs and other domestic animals that have swallowed some poisons.

An nausea-causing effect that is worse than the nausea-causing effect of straight L-dopa and mucuna pruriens is the most common side effect of dopaminergics.

While apomorphine has been tried as a pleasure drug, this is about all it has in common with its more famous colleague in name, morphine. Sure, apomorphine is produced from morphine. But its pharmacological effects are completely different. Morphine is a sedative agent, while apomorphine is a stimulant.

Apomorphine is a typical dopamine agonist, which accounts for its, albeit limited, usefulness in the management of Parkinson’s disease.

Apomorphine is a D1 receptor-specific dopamine agonist that makes it different from mostly ergot-derived dopamine agonists, which usually target D2 dopamine receptors, e.g. pergolide and bromocriptine. D3 and D4 dopamine receptors are less often targeted in the treatment of Parkinson’s.

It has long been documented that most Parkinson’s medications have sexuality-enhancing side effects. I was personally using mucuna pruriens and Parkinson’s medications for sexual enhancement long before Uprima was launched. I gained the most experience with L-dopa and mucuna pruriens, but I have also tested Parlodel (bromocriptine), Dopergine (lisuride), Cabergoline (brand name: Dostinex), Mirapex (pramipexole), and deprenyl.

It has to be noted that the sexuality-enhancing side effects hold true for many but not all dopamine-enhancing Parkinson’s medications. Whether or not a dopamine agonist enhances sexual functions seems to depend primarily on the dopamine receptor and sub-receptor sites it targets.

Unlike sildenafil citrate, L-dopa, mucuna pruriens, and dopamine agonists, whether Uprima or Dostinex), exert their pro-sexual effect not upon the erectile organ but upon the brain. They provoke erections not by improving the plumbing of male sexual function (i.e. blood supply to the penis), but by interfering with the wiring necessary for arousal, pleasure, and climax.

That sildenafil citrate only affects the plumbing, puts limits to its potential as a lifestyle drug. Sildenafil citrate will add little for men whose plumbing doesn’t leak, and apart from that, sildenafil also causes headache in many users, and comes with a risk of stroke. On the other hand, a good shot of additional desire is a welcome life enhancement for many people with whom there is nothing wrong physically but who just feel bored with their everyday life. For them, L-dopa, mucuna pruriens, and, on a more limited scale, dopamine agonists can be a real enrichment, and even a medication that saves their marriages.

Dosage for a pro-sexual effect is easier to determine for L-dopa and mucuna pruriens than for dopamine agonists. This is the case because a dosage that is too high will inevitably result in bad nausea. This nausea can be so bad that the last thing one fancies is sex. This particularly is a problem with apomorphine.

One of the advantages of straight L-dopa and mucuna pruriens is the fewer side effects.

Uprima has never been approved for marketing in the US, and it has meanwhile been withdrawn from Europe as a treatment for sexual dysfunction (it is still around as a veterinary emetic). The point is, apomorphine is inferior to mucuna pruriens on all counts, except profitability for pharmaceutical companies.


Read about marijuana and tongkat ali extract for meaningful sex

or

Read a tell-it-all about Indonesian 1:200 extract (and a psychopath on the prowl for killings)



Tongkatali.org's What is aging?


By Serge Kreutz


Aging, from a certain age onwards, is a decline of physical and mental functions.

It partially depends on outside impact (accidents and illnesses caused by external pathogens), and partially is self-regulated (the human body withdraws itself from life).

This article deals only with aging as a result of negative self-regulation.

Negative self-regulation is heavily mediated by the immune system of the human body.

The immune system takes its clues for negative self-regulation from the neurological system which signals to the immune system, on multiple pathways, that time is approaching (for the benefit of the species) to let the next generation take over.

The genetic make-up of human nature may determine that it is in the interest of the species that I, as a human male, vacate my social positions, and the surface of this planet rather sooner than later.

But this is not my individual interest. As long as I can have fun, I want to be around.

Any serious life extension has to take this into consideration: if you want to live longer, you have to intercept the negative self-regulation of the immune system.

And the healthiest way (free of side effects), is by interfering with the negative signaling of the neurological system.

And how do you control the neurological system?

One powerful way to do this is via the psychological system.

This is why a positive attitude towards life has such a great positive impact on a persons immune system, and his or her health.

Go further!

It is the psychological-relationships system of human physiology that has the greatest power over how we feel.

Our greatest capacity to feel well, and positive, is when our minds are engulfed in relationships desire, and after that, during the waves of orgasms.

Because these positive situations recharge our immune system like nothing else, our health is great as long as we have great relationships. No rheumatism, no back aches, no high blood pressure, no cancer (and an endless list of other “no’s”).

So, what practical conclusions we can draw from this if our aim is to slow down aging?

We have to ensure that our relationships lives are as optimal as they can be.

For this reason, I am against all social orders that have a negative impact on my personal relationships life. Such social orders deprive me of better health and bring me closer to death.

On the other hand, I do recognize that the quality of my relationships desires and orgasms considerably depend on my hormonal balances, especially the levels of testosterone.

This is why the only drug in my personal life extension regimen is a substance that up-regulates my testosterone levels.

Actually, it’s not even a drug but a herbal supplement, the testosterone-enhancing effect of which has been well documented in scientific research: tongkat ali

Please be aware that while I am all in favor of elevated testosterone levels, I am totally opposed to exogenous testosterone (testosterone patches, testosterone injections, anabolic steroids).

Why?

Because my health, and any life extension I can achieve, depend on whether I have a healthy hormonal system. And supplying exogenous testosterone is the worst interruption that can happen to my endocrine functions. Exogenous testosterone just throws everything out of balance. This is the opposite of what I can achieve with tongkat ali.




Tongkatali.org's Neuropharmacological help


By Serge Kreutz


One could consider any state of mind that is not sheer bliss an imbalance, or a neurological deficiency, or an outright illness.

Nature and evolution have, through natural selection, tricked mankind into being unhappy because unhappy subjects strive harder. So, most people genetically are descendants of unhappy winners.

Sooner or later, genetic engineering and neuroscience will correct nature. Maybe humans in the fourth millennium will be born with a genetic guarantee for a happy life, no matter what the conditions they actually live in will be.

Before that time, neurosurgery may do a good job to correct chronic unhappiness by cutting short the firing lines of some neural circuits. But certainly not by just drilling holes into the brains of unhappy people, as was done with lobotomies in the 1950s.

For now, mankind has at hand just a number of pharmacological solutions. How good people feel depends a great deal on the level of neurotransmitters at nerve synapses. Pharmaceuticals can upscale neurotransmitters, mostly serotonin, and that’s what anti-depression medications are mostly about. The most widely used anti-depression medications are SSRIs, Selective Serotonin Reuptake Inhibitors. They interfere with the degradation of serotonin, thereby assuring that levels of serotonin stay higher than they otherwise would.

Many people could just take some Prozac, and by-and-large, be happier than they are now. But becoming happier would also make them less competitive.

In order to achieve the goal of great relationships, a lot of preparatory work needs to be done, and to have it done requires competitiveness. One has to take care of one’s appearance. One has to study social conditions in order to know where they are favorable.

And one has to work on one’s capability to enjoy those moments for which one lives. Erection problems, or the failure to have a satisfying climax, are disturbances, not only to the mood but also to the whole system of values of Kreutz Ideology.

But like happiness itself, relationships desire, erections, and orgasms, too, are matters of engineering. They are mechanical problems of wiring (nerves) and plumbing (blood vessels).

Currently, the only effective method to interfere with the neuromolecular basis not only for happiness but also relationships desire, are pharmaceuticals.

Yohimbe (with the pharmacologically active ingredient yohimbine) is effective, though, unfortunately, it also is very side-effective. It helps somehow with the wiring. Though not a MAO inhibitor, yohimbe does feel as if it elevates dopamine levels. One feels agitated, even though blood pressure is lowered by yohimbine.

Anything that raises dopamine levels is likely to have a positive effect on desire. That’s why practically all medications for Parkinsonism cause increased relationships interest. (Parkinsonism is a pathological depletion of the neurotransmitter dopamine through interference with the dopamine production sites in the brain.)

The main effect of yohimbine is on the plumbing. Yohimbine blocks presynaptic alpha-2-adrenergic receptors, resulting in increased blood flow to the relationships organs, and in reduced outflow. Thus better erections can be engineered, and because of the increased pressure in the relationships organ, there is also increased pleasure, and the experience of orgasms can be heightened, though this is not guaranteed.

Bromocriptine is a prescription Parkinson medication (Parlodel by Sandoz), which also reduces prolactin levels. It helps in relationships intercourse primarily because it raises desire. In many cases, this will lead to better erections, too, though the effect may not be as pronounced as what is achieved by pharmalogical agents acting directly on the plumbing. But bromocriptine can make for memorable orgasms.

Deprenyl is another prescription Parkinsonism medication, a selective MAOI blocker. I do find that it raises desire but it also leads to some shrinkage, similar to what people experience on amphetamines.

DHEA has been hyped for years. It simply has no effect on relationships parameters.

Gingko Biloba is an herbal product that presumably increases the blood flow to the extremities, including the brain and the relationships organs. Hyped but useless for relationships.

Arginine is an amino acid and nitric oxide precursor. It has been much touted as an erection booster but one never notices even the slightest effect.

Pfizer’s Blue obviously works.

Scientifical research indicates tongkat ali raises the body’s own testosterone production, and this could have a positive effect on several relationships parameters.



Tongkatali.org's Impotence or erectile dysfunction


By Serge Kreutz


Impotence is now medically referred to as erectile dysfunction. But impotence is more than just erectile dysfunction. It is lost maleness.

Impotence is a condition much more complicated than most diseases. Many diseases are single-cause conditions.

A specific virus causes the flu or hepatitis, and specific bacteria cause tuberculosis. Many other conditions are, by and large, single-symptom diseases. A broken bone, a cataract of the eye, or the shingles are easy to diagnose. There are clear symptoms that usually apply to just that health problem. Erectile dysfunction cannot be defined like this.

While “erectile dysfunction” has become the term of choice among doctors and educated patients, it’s probably less accurate a description of what’s wrong than the old word “impotence”. “Erectile dysfunction” is a technical term, and it sounds much less embarrassing than “impotence”.

But the general idea of lost maleness carried by the word “impotence” actually describes more precisely the implication of the condition discussed here. Impotence is more than just erectile dysfunction… it may or may not be a blood-vessel insufficiency. But it may also be a loss of desire regulated by a certain neurotransmitter balance. It may have hormonal or psychological causes, or it may be a problem of sympathetic and parasympathetic nerve impulses. Erectile dysfunction, a lack of erection, is just a part of the condition impotence. Assuring an appropriate blood pressure in the male relationships organ does not solve the problem. That’s why erection injections and erection pumps (see youtube here) are not satisfactory by themselves. An erection without desire is a waste of effort (and money), and desire without the capability of a definite orgasm results in frustration rather than satisfaction.



Neuroprotective effects of the antiparkinson drug Mucuna pruriens

Bala V. Manyam Muralikrishnan Dhanasekaran Theodore A. Hare

Abstract

Mucuna pruriens possesses significantly higher antiparkinson activity compared with levodopa in the 6‐hydroxydopamine (6‐OHDA) lesioned rat model of Parkinson's disease. The present study evaluated the neurorestorative effect of Mucuna pruriens cotyledon powder on the nigrostriatal tract of 6‐OHDA lesioned rats. Mucuna pruriens cotyledon powder significantly increased the brain mitochondrial complex‐I activity but did not affect the total monoamine oxidase activity (in vitro). Unlike synthetic levodopa treatment, Mucuna pruriens cotyledon powder treatment significantly restored the endogenous levodopa, dopamine, norepinephrine and serotonin content in the substantia nigra. Nicotine adenine dinucleotide (NADH) and coenzyme Q‐10, that are shown to have a therapeutic benefit in Parkinson's disease, were present in the Mucuna pruriens cotyledon powder. Earlier studies showed that Mucuna pruriens treatment controls the symptoms of Parkinson's disease. This additional finding of a neurorestorative benefit by Mucuna pruriens cotyledon powder on the degenerating dopaminergic neurons in the substantia nigra may be due to increased complex‐I activity and the presence of NADH and coenzyme Q‐10.

https://doi.org/10.1002/ptr.1514




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