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Prolactin anti-sex depression hormone, and the L-dopa, mucuna pruriens antidote

By Serge Kreutz

This article builds on the scientific hypothesis (or, for the less scientifically minded, the assumption) that the hormone prolactin is a multiple culprit.

Obviously, prolactin also has its useful sides. As its name indicates, it is essential to initiate and maintain lactation in women who are about to give birth, or have been given birth. It also stimulates the secretion of progesterone, which has, as this hormone’s name indicates, an important function in gestation.

Other effects of prolactin are less useful to modern man (which, grammatically and linguistically, includes the females of the species). I am referring to prolactin’s power to down-regulate the effect of several other important hormones (especially testosterone), as well as some neurotransmitters (such as dopamine).

Prolactin is the ultimate sex drive killer. Women who have given birth, and men who have been the sexual partners of such women, know that a woman’s sex drive can almost completely disappear for some time after having given birth and as long as breast-feeding is maintained.

And it is no secret to the medical community that the sex drive of men and women who suffer from a prolactinoma (cancer of the pituitary gland that causes gravely increased output of the hormone prolactin) is practically nil.

While only a certain percentage of all people suffer from prolactinomas, there is a clear tendency for almost everybody to have gradually increased levels of prolactin levels as one progresses in age. As is determined by our evolutionary development, it is best for the human species in its fight for survival (against other species) when species members of the age between puberty and, let’s say, 30 are those who normally produce offspring.

Therefore, it should come to no surprise if physiological traits have developed over time which assure that younger members of the species are biologically better positioned to produce offspring than the older generation. Increased prolactin levels as we age certainly are one mechanism that works to this effect.

But what is best for mankind is not best for each and every individual. By means of genetic make-up, we, as individuals, are designed to vacate the surface of this planet when we have reached an age of, normally, less than 100 years. Crocodiles and parrots, and especially turtles, live much longer, up to hundreds of years, and some trees make it well beyond 1000 if they aren’t murdered by man.

There is no logical reason why we should not imagine to live for thousands of years, once we have defeated mischievous mother nature, who, among other tricks, uses prolactin levels, which increase with age, to make sure that we don’t compete with younger generations for the right and pleasure to have sexual intercourse. Prolactin’s role, apart from initiating and maintaining lactation, clearly is one of down-regulating sexual instinct.

It doesn’t do so only by interfering with testosterone. High prolactin levels are also reversely related to our sense of well-being, or directly related to depression. There is a correlation between sufficiently high testosterone levels and sufficiently high levels of the neurotransmitters dopamine on the one side of the equation, and a general high motivation to get on with one's life on the other side.

When in the US, Andrea Yates murdered her children, the term “postpartum depression” became a household word. Her irrational behavior was linked to this condition. Postpartum depression is not uncommon, though it doesn’t usually lead to infanticide. And it develops parallel to increased prolactin levels, necessary to initiate and maintain lactation.

I have mentioned initially that this article is based on the scientific hypothesis, or the assumption, that prolactin is a multiple culprit in age-related sexual dysfunction. I am not preaching this theory as the final truth.

However, in order to progress with cognition, we will have to proceed through hypotheses. Hypotheses are based on circumstantial evidence. And there is plenty of circumstantial evidence that indeed, prolactin regulation is the key to improving many conditions of sexual dysfunction.

Strong circumstantial evidence also is provided from the use, and experimentation, with medications that effect prolactin levels. Lowering prolactin levels is commonly achieved with dopaminergic medications, used in the treatment of Parkinson’s. Some of these medications, such as lisuride, cabergoline, bromocriptine, and L-dopa have the reputation to be useful for sexual enhancement.

I have tried some of these, and I definitely cannot recommend them for casual use. Some of them make healthy people feel terribly nauseated.

The most gentle way to reduce high prolactin levels in men and women is via mucuna pruriens.

L-dopa, which is the main active ingredient in mucuna pruriens, has been shown in numerous scientific studies to lower prolactin. Everybody can search for such studies via: scholar.google.com

Mucuna pruriens' prolactin-lowering effect, of course, is a direct result of its content of L-dopa. But buyers should be aware that the L-dopa content in mucuna pruriens varies dramatically. Indian mucuna pruriens cultivars that have been developed as animal feedstock are virtually void of L-dopa. Wild Thai mucuna pruriens, on the other hand, is particularly rich in natural L-dopa.

If one's aim is a highly sexualized life-style until old age, the aim must be to permanently suppress high prolactin levels.

What a human body considers an age-related prolactin homeostasis is genetically set. For practically everybody, the bias is towards lower prolactin levels in his or her youth, and towards higher prolactin at a later age. And as studies indicate, unlike synthetic L-dopa which loses effectiveness over time, mucuna pruriens can be consumed for many years, even decades.

With low prolactin levels, we can have the most satisfying sexual experiences of our lifetimes, whatever our age may be.